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KMID : 0861020180330050047
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Korea Journal of Herbology
2018 Volume.33 No. 5 p.47 ~ p.52
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Mixture Bombyx mori L. and Liriopis seu Ophiopogonis Tuber effects on T cells in Thymus, Lymph Nodes
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Kim Il-Gyu
Park Hae-Jin
Kim Kyeong-Jo
Kim Soo-Hyun
Kim Min-Ju
Lee Jin-A
Roh Seong-Soo
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Abstract
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Objectives : The purpose of this study is to investigate effects on the immune system of Bombyx mori L. and Liriopis seu Ophiopogonis Tuber mixture (BL) in Thymus, Lymph Nodes.
Methods : Eight-week-old male Balb/c mice were divided into five groups : Group one included the normal mice (Nor). Positive control group two administrated with red ginseng (RG) 100 mg/kg . Group three administrated with Bombyx mori L. (BX) 300 ㎎/㎏. Group four administrated with Liriopis seu Ophiopogonis Tuber (LP) 300 ㎎/㎏. Group five administrated with the mixture of Bombyx mori L. and Liriopis seu Ophiopogonis Tuber (BL) 300 ㎎/㎏. After 2 weeks administration, mice were sacrified and antigen receptor in Thymus, Lymph Nodes was analyzed by using Fluorescence Activated Cellorter Sorting (FACS). we counted the total of Thymus and Lymph Nodes cells. GOT (glutamlc oxaloacetic transaminase), GPT (glutamlc pyruvic transamlnase) in serum were analyzed after experiment.
Results : In Effects of Nor, RG, BX, LP, BL on the ratio of CD4+CD8+, CD4+CD69+ and CD4+CD25+ T cell in Thymus and Lymphnode, BL is higher than other groups except Nor in CD4+, CD4+CD69+, CD4+CD25+ T cell. The number of Thymus and Lymph Nodes increased in BL. In the level of GOT and GPT, BL decreased comparing to others group except Nor.
Conclusions : BL may have effect on T cells in Thymus, Lymph Nodes. In addition, Bombyx mori could be immune functional material with others herb materials.
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KEYWORD
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Bombyx mori L., Liriopis seu Ophiopogonis Tuber, Thymus, Lymph Nodes, T cell
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